Bradford Bulls will face Kingstone Press Championship One opponents in the fourth round of the Tetley's Challenge Cup.
They will travel to Rochdale Hornets on the weekend of April 20-21.
Keighley Cougars, however, have again pulled out plum opponents in holders Warrington Wolves.
They will visit the Kingstone Press Championship club for the second year in a row.
The Wolves gained a 44-18 fourth-round win last April on their way to winning the trophy at Wembley for the third time in four years.
Last year's beaten finalists Leeds, the current Super League champions, have been paired with Castleford in one of two all-Super League ties.
The Tigers beat the Rhinos 14-12 in round two of Super League in February but are without a win since then and are currently bottom of the table.
Hull KR, who beat St Helens 22-14 at Craven Park in Super League yesterday, will host the same opposition in the other all top-flight clash and there are two inter-league derbies at Wigan, who will host Leigh, and Batley, who are at home to Huddersfield.
There will be at least three Championship clubs in the last 16 after six of them were paired together, while French club Toulouse will be hoping to follow up their third-round win at Swinton by toppling York.
Fourth-round draw: Wigan v Leigh, Hemel v Wakefield, Hunslet v Catalan Dragons, Rochdale v Bradford, Batley v Huddersfield, Hull v North Wales, Sheffield Eagles v Dewsbury, London Broncos v Featherstone, Halifax v Barrow, Widnes v Doncaster, Keighley v Warrington, Leeds v Castleford, University of Gloucestershire v Salford, York v Toulouse, Whitehaven v Workington, Hull KR v St Helens. Ties to be played on the weekend of April 20-21.
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