Bradford bobby Dean Maddocks plans to pull no punches when he meets the Prime Minister tomorrow.
PC Maddocks and his wife, Carol, aim to hold Tony Blair to a promise made on national television in May - that he would help save their youngest daughter's life.
Eight-year-old Alice Madd-ocks suffers from a rare condition called severe aplastic anaemia, which stops her bone marrow from producing enough red and white blood cells to protect her.
Her only hope for a cure is to have a bone marrow transplant but first she has to find a matching donor - and only a tiny percentage of the UK population is currently registered.
That is something her parents hope their meeting with Mr Blair will change. Their meeting with him follows their appearance on BBC1's Question Time programme when they confronted him during a live debate.
PC Maddocks, 38, of Bradford South Police, said: "We will tell Tony Blair that bone marrow donations are a life-saving, essential thing, and shouldn't have to rely on charities.
"We want the Government to set up a fixed budget, a centrally managed register backed by a full awareness-raising campaign which would dramatically boost the number of potential donors."
As it stands, possible donors have to join either with the Anthony Nolan Bone Marrow Trust, a charity, or the National Blood Service register - which Mr Maddocks said was not actively promoted.
The Maddocks are angry that such a vital service is available only in a piecemeal way.
And PC Maddocks added that while more than two million people regularly give blood, only seven per cent of them are on the bone marrow register.
He said: "We know there are so many more donors out there that don't know the registers even exist, because the groups running them don't have the money to promote the fact.
"We're not fazed at all about meeting Mr Blair, because he knows that not everything is being done that could be. We're not going in there asking for something that's impossible.
"We want the whole effort to be co-ordinated and funded by Government centrally, and for the number of registered donors to be at least doubled in the short term. We're not just doing this for Alice. The more people who register the better chance a lot of other kids, and adults, have."
Alice, who has to receive constant treatment and blood transfusions while the search for a donor goes on, will rest with her grandparents while her parents visit Mr Blair.
The couple have collected more than 6,000 signatures backing their campaign, which is being supported by Prince Charles, Esther Rantzen and Sir Alex Ferguson.
l Anyone wishing to become a potential bone marrow donor should contact the National Blood Service on 08457 711711 or call the Anthony Nolan Bone Marrow Trust on (0207) 284 1234. For details on how to help Alice visit her website at www.helpalice.org.
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