The A65 between Skipton and Gargrave was closed in both directions Saturday evening after a two-car crash near Thorlby.
Firefighters from Skipton freed a woman driver, in her 30s, who was trapped in her car. She was taken to hospital with pelvic injuries.
Her female passenger, in her 40s, suffered head injuries and was also taken to hospital.
A second car had overturned but the male driver was reported to be uninjured.
The road was closed from about 5.30pm until well into the evening.
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